Subcellular compartmentalization of MBNL1 plays a key role in regulation of neurite differentiation and its disruption may contribute to CNS defects in DM.
Close monitoring of respiratory function reduces respiratory complications in DM1.
A new publication details organization of and data from a Canadian neuromuscular disease registry.
A new scoring system identifies key risk factors and a novel tool for assessment of DM1 patient life expectancy.
Speech disorders (dysarthria) in CDM and childhood-onset DM1 have long been recognized and surveillance by speech and language therapists is an important aspect of patient care. Facial weakness and myotonia, and involvement of oral cavity, palatopharyngeal and respiratory muscles, are known to contribute to speech impairment.