Circular RNAs that play a role in myogenesis are dysregulated in DM1 skeletal muscle.
A new study examines approaches to determine DM1 study subject progenitor allele length.
Multivalent ligands show bioavailability and efficacy in targeting splicing defects in DM1.
Antisense oligonucleotides – short segments of genetic material designed to target specific areas of a gene
The new approach could have implications for many genetic diseases.