The RNA binding protein, rbFOX1, competes with MBNL in binding to CCUGexp, but not CUGexp repeats, and thereby mitigates DM2.
The review journal, Frontiers in Neurology, is publishing six new articles on myotonic dystrophy.
Intronic GC-rich microsatellite expansions are common in neurological disorders and act to trigger the intronic retention that underlies disease pathogenesis.
Methodology is reported for robust and reliable quantification of mutant and abberantly spliced RNA in cells from DM patients.
NIH announces intent to reissue a Funding Opportunity Announcement for the Rare Disease Clinical Research Network competition.