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Myotonic dystrophy is associated with a modest reduction in the amount of immunoglobulin in the blood (hypogammaglobulinemia). The production of antibodies is normal, however the antibodies do not last as long in the circulation, hence the amount in the blood at any time is somewhat reduced.

People with myotonic dystrophy DM1 have an increased frequency of pilomatrixoma, a type of benign skin tumor. This type of tumor is rare in the general population but fairly common in people with myotonic dystrophy DM1. (No association between pilomatrixomas and DM2 has been reported).

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