The RNA binding protein, rbFOX1, competes with MBNL in binding to CCUGexp, but not CUGexp repeats, and thereby mitigates DM2.
The review journal, Frontiers in Neurology, is publishing six new articles on myotonic dystrophy.
MDF updates information on the Department of Defense’s Peer Reviewed Medical Research Program first described in the April Research News.
NINDS has a strong program to support preclinical therapy development and has released three additional initiatives to support work in academia or industry.
Intronic GC-rich microsatellite expansions are common in neurological disorders and act to trigger the intronic retention that underlies disease pathogenesis.